Week 1 Picks: Seahawks/49ers a tone-setter | Can the Bengals defeat September?

Update: 2025-09-05

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Segment 3 of our Week 1 picks includes Bengals @ Browns in what could be key to Cincinatti's season, Raiders @ Patriots where Shane is confident, Dolphins @ Colts where Daniel Jones is backed. In the late window, 49ers @ Seahawks is a mouth-watering divisional duel, as Titans @ Broncos sees Cam Ward line out for the first time in the NFL.

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